Did you know that many cardiovascular diseases vary by sex as well as by age? Men with heart failure die off at a faster rate than women, regardless of treatment. But this cardio-protective quality for females is predominantly found in pre-menopausal women, not post-menopausal women. (JMM)
German researchers studied the molecular basis for these hormonal differences, using gene expression profiling on mouse and human cardiac samples. Equipment included an Agilent Bioanalyzer system, cDNA microarrays, microarray scanner and software.
In total, the researchers found that gene expression of 13 mouse genes and 14 human genes differed between males and females, regardless of age. They also found that most of these distinctly expressed genes were located on sex chromosomes.
The researchers hope their findings “may represent a starting point for an improved gender-specific medicine.”
For Research Use Only. Not for use in diagnostic procedures.
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For more information go to:
- History of Valentine’s Day (History)
- American Heart Month (U.S. Department of Health and Human Services)
- Sexually dimorphic gene expression in the heart of mice and men (Journal of Molecular Medicine)
- Agilent Bioanalyzer Automated Electrophoresis
- Agilent Gene Expression Microarray Platform
- Agilent Gene Expression Microarray Scanners & Equipment
- Agilent miRNA Microarray Software