It’s difficult enough to lose weight. It’s even more difficult to keep that weight off. Worst of all, it appears your body actively works to undermine your dietary resolve.
Danish researchers recently discovered that after people lose weight, their bodies begin producing 23 percent more ghrelin. Ghrelin is the hormone that makes you feel hungry. Apparently, your body thinks there’s something wrong and starts kicking your appetite into high gear. So those post-diet hunger pangs you’re feeling aren’t imaginary. You can blame your hormones.
On the positive side, the researchers also discovered that this ghrelin spike subsides over the following year, as your body gets used to its lighter weight. So the trick is to keep those pounds off for 12 whole months. Then you are likely to be much more successful at maintaining the new you.
Agilent technologies have been used to research the properties of ghrelin.
Diets that are high in dietary fiber are reported to have substantial health benefits. U.S. researchers tested mice with three kinds of fiber diets. Sugarcane and psyllium fiber diets had significantly lower body weight gains than cellulose diets. The sugar cane diet also resulted in significantly lower ghrelin levels. The researchers used an Agilent Nano LabChip kit for RNA analysis and quantitation.
Anorexia nervosa is a life-threatening eating disorder, characterized by self-starvation and excessive weight loss. Anorexia is also a major factor behind progressive weight loss in cancer. Swedish researchers administered ghrelin to mice with cancer-induced anorexia, to see if ghrelin treatment would improve the mice’s health.
Normal mice saw increased food intake, body weight and whole body fat with ghrelin treatment. But tumor-bearing mice only showed improvements with high doses of ghrelin. Tumor growth was not altered. This confirms that other factors appear to be more important than ghrelin to explain cancer-induced anorexia. The researchers used an Agilent Bioanalyzer system to check the quality and quantity of RNA, DNA and PCR.
For more information go to:
- If You Can Maintain Weight Loss For a Year, It Gets Easier (Men’s Health)
- Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3–36
- Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet
- Effects of ghrelin on anorexia in tumor-bearing mice with eicosanoid-related cachexia (PDF)
- Agilent Genomics Solutions