Agilent Improves Instrument Resolution and Sensitivity by 5X

Agilent has introduced a new analytical instrument that provides up to five times more resolving power and sensitivity than earlier instruments.

The Agilent 6545 is in the mid-range of its Q-TOF LC/MS portfolio.  These sophisticated instruments are used by analytical laboratories to detect and identify unknown samples of everything from chemicals to foods to forensic evidence.

(“Q-TOF LC/MS” stands for “quadrupole time-of-flight liquid chromatograph/mass spectrometer.”)

“Customers tell us that sensitivity is becoming one of their most important requirements,” says Agilent’s Dr. Ben Owen.  “Users cannot afford to miss low-intensity compounds.  And they need this sensitivity to go across a wide range of applications.”

The 6545 includes several cutting-edge advances in both hardware and software, including new ion optics, new tuning technology and high-voltage power.  The instrument can detect more compounds at very low levels, with mass accuracy of less than 1 part per million.

The new instrument fills out Agilent’s family of QTOF offerings:

  • The entry-level Agilent 6530 accommodates budget accounts. It is ideal for chemical and forensic applications.
  • The mid-range Agilent 6545 offers the greatest value. It is ideal for food safety and environmental screening.
  • The high-end Agilent 6550 provides maximum sensitivity. It is ideal for proteomics, metabolomics and glycomics.

“The 6545 Q-TOF offers a substantial leap forward in sensitivity, while maintaining all other features one expects from a high-end Q-TOF system,” says Dr. Koen Sandra of the Research Institute for Chromatography.

“The 6545 Q-TOF can be a workhorse in both targeted and untargeted profiling of small molecules in a wide range of applications.  We were suddenly able to elucidate impurities in pharmaceutical samples that we overlooked in the past.”


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