A Heart-Cutting Award for Agilent

Agilent has received a technology award from The Analytical Scientist magazine.

When a laboratory analyzes an unknown sample, it typically uses a two-step process of separation followed by detection.  In gas and liquid chromatography, separation is accomplished by passing the sample through a tube-like column, where a solvent separates it into simpler components for analysis.

With complex samples, however, there are often too many overlapping compounds to obtain a complete separation, even with the highest-resolution columns available.

One solution is “multidimensional” chromatography, also known as “2D” or “heart cutting.”  A small fraction of the compound is “cut” or transferred from the first column to a second column.  Data is thus acquired from two detectors, enhancing the resolution of the cut section.  But 2D technologies have had issues with repeatability, precision and robustness.  Data points from the first dimension can be lost while the second dimension is running.

The Agilent 1290 Infinity II Multiple Heart-Cutting 2C-LC solution solves this problem with multiple heart-cutting abilities, enabling users to increase performance in the second dimension without losing data from the first dimension.  This fully automated solution has now been recognized by The Analytical Scientist Innovation Awards 2014 as one of the most transformative technologies introduced in the past year.

“Good to see that relatively complex/challenging analytical flow technology can be automated in a robust way,” said the judges.

“The Agilent 1290 Infinity II 2D-LC solution with multiple heart-cutting boosts analytical efficiency with superior peak capacity compared to conventional solutions,” said Agilent’s Stefan Schuette.  “It improves laboratory efficiency by providing unmatched ease of use.”


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