Phthalate esters are man-made substances that are added to plastics to increase their flexibility, transparency and longevity. Because they do not actually bond to the plastics, they are easily released into the environment. Humans can be exposed to phthalates by handling associated products or even from contact with dust around the house. Phthalate exposure has been linked to hormone level changes, birth defects and cancer in animals.
Previous studies have shown that patients with intravenous (IV) drips are exposed to several phthalates that leach into the solution from the PVC bags. Now, Chinese scientists have discovered a similar risk from aerosol inhalers.
The U.S. Food and Drug Administration has noted an increased likelihood of interactions between the packaging and contents of such devices. Researchers from the Shanghai Institute of Pharmaceutical Industry and the Shanghai Institute for Food and Drug Control studied 21 different phthalate esters. Results showed the presence of five phthalates in metered dose inhalers. While levels were well below the recommended daily intake, the research team recommended that manufacturers “should still pay close attention to leachable phthalate esters to ensure quality and safety of their products.”
Scientists used an Agilent 7890 GC, 7000 GC/MS Triple-Quad and J&W DB-5ms column in their research.
This information is for research purposes only. It is not intended for any use in diagnostic procedures.
For more information go to:
- Analysis of 22 phthalate leachables in metered dose inhalers by gas chromatography tandem mass spectrometry
- Inherent to inhalers: Phthalates leach into pharmaceutical contents (separationsNOW)
- Drip feeding phthalates: Several phthalate esters found in intravenous solutions (separationsNOW)
- Agilent 7890 Gas Chromatograph
- Agilent 7000 GC/MS Triple-Quad
- Agilent J&W DB-5ms Column